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. 2020 Aug 27;12(9):1591–1603. doi: 10.1093/gbe/evaa178

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5. — Gene-orientation mutation bias evolves in the LTEE. The x axis is the reference genome, centered on the replication origin, partitioned into 46 equally sized bins of ∼100 kb. In each labeled subfigure, top and bottom panels show genes occurring on each of the two strands of the chromosome, with the arbitrary labels 1 and −1. (A) The nucleotide composition of genes on the two strands of the chromosome of the LTEE ancestral clone REL606. (B) The genomic distribution of mutations within genes, summed over MMR-deficient LTEE populations (left panel) and MutT-deficient LTEE populations (right panel).