Fig. 6.

One hypermutator LTEE population, Ara+3, shows a strong wave pattern of mutation rate variation centered on the replication origin. Each panel shows the genomic distribution of mutations observed in each hypermutator LTEE population in the metagenomics data. The x axis is the reference genome, centered on the replication origin, partitioned into 46 equally sized bins of ∼100 kb. Indels are in purple, missense mutations are in dark blue, noncoding mutations are blue green, nonsense mutations are sea green, sv are green, and synonymous mutations are yellow.