Fig. 7.

MMR-deficient LTEE populations (excluding Ara+3) show a weak wave pattern, whereas MutT-deficient LTEE populations show no wave pattern. The left panel shows the genomic distribution of mutations observed in Ara−2, Ara−3, and Ara−4. The right panel shows the genomic distribution of mutations observed in Ara−1 and Ara+6. The x axis is the reference genome, centered on the replication origin, partitioned into 46 equally sized bins of ∼100 kb. Indels are in purple, missense mutations are in dark blue, noncoding mutations are blue green, nonsense mutations are sea green, sv are green, and synonymous mutations are yellow.