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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Expert Opin Pharmacother. 2020 Apr 15;21(11):1319–1328. doi: 10.1080/14656566.2020.1748599

Figure 1. Changes in weight (%) and BP (mmHg) relative to placebo at 1 year.

Figure 1.

*Orlistat associated weight change is based on various meta-analyses and systematic reviews that included different RCTs of various durations. Orlistat-associated change in blood pressure is based on a recent meta-analysis [99]. For all other drugs, the results are based on pooled data of phase 3 RCTs in patients with obesity without diabetes as drawn from the FDA advisory committee briefing documents. When more than one dose was studied, results shown are the ones for the most effective dose. All data are from ITT analyses. [100].