. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: Ann Neurol. 2020 May 7;88(1):56–66. doi: 10.1002/ana.25740

Table 3:

Study-specific and metanalysis of logistic regression results modeling ICH risk as a function of different PRS.

Study	Total Cholesterol		LDL Cholesterol		HDL Cholesterol		Triglycerides
Study	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
GOCHA	0.95 (0.80 – 1.14)	0.59	0.93 (0.78 – 1.11)	0.41	1.12 (0.94 – 1.34)	0.20	0.95 (0.80 – 1.14)	0.59
ISGC ICH	0.93 (0.82 – 1.05)	0.24	0.88 (0.77 – 0.99)	0.04	1.15 (1.01 – 1.30)	0.03	1.01 (0.89 – 1.14)	0.84
GERFHS	0.88 (0.77 – 1.01)	0.07	0.85 (0.75 – 0.97)	0.02	0.99 (0.86 – 1.12)	0.84	1.19 (1.04 – 1.36)	0.009
Fixed effects Meta-analysis	0.92 (0.85 – 0.99)	0.03	0.88 (0.81 – 0.95)	0.002	1.10 (1.00 – 1.21)	0.06	1.11 (0.98 – 1.23)	0.14
Random Effects Meta-analysis	0.92 (0.84 – 0.99)	0.03	0.88 (0.81 – 0.95)	0.002	1.08 (0.98 – 1.19)	0.13	1.05 (0.93 – 1.20)	0.42
Heterogeneity	I²=0%	0.77	I²=0%	0.75	I²=32%	0.23	I²=60%	0.08

Acronyms: ICH: intracerebral hemorrhage; PRS (polygenic risk score); LDL: low-density lipoprotein; HDL: high-density lipoprotein; CI: confidence interval; GOCHA: Genetics of Cerebral Hemorrhage with Anticoagulation; ISGC: International Stroke Genetics Consortium; GERFHS: Genetic and Environmental Risk Factors for Hemorrhagic Stroke; FE: Fixed-Effects. RE: Random effects. Het-p: heterogeneity-p for the metanalysis.