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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Ann Neurol. 2020 May 7;88(1):56–66. doi: 10.1002/ana.25740

Table 6.

Sensitivity MR analyses evaluating the effect of genetically-determined LDL cholesterol on risk of different types of ischemic stroke: comparison of results using effect estimates for lipids using GLGC and the UK Biobank.

Ischemic stroke subtype Lipid estimates from the GLGC 2019 Valdes-Marquez et al* Lipid estimates from the GLGC 2018 Hindy et al** Lipid estimates from the UK Biobank (this study)
Cardioembolic 1.06 (0.84 – 1.33) 0.99 (0.84 – 1.16) 1.05 (0.97 −1.13)
Large artery 1.10 (0.82 – 1.47) 1.28 (1.07 – 1.53) 1.37 (1.24 – 1.51)
Small vessel 1.14 (0.88 – 1.48) 1.09 (0.93 – 1.28) 1.12 (1.03 – 1.22)

Acronyms: MR: Mendelian Randomization; LDL: low-density lipoprotein; GLGC: Global Lipids Genetics Consortium; UK: United Kingdom.

*

Neurology. 2019 Mar 12;92(11):e1176–e1187.

**

Stroke. 2018 Apr;49(4):820–827.