TABLE III.
Toxicities by Tertiles of Whole-Body Radiation Dose
| AH 131I-MIBG Protocolsa | |||||
|---|---|---|---|---|---|
| Toxicity | All | Tertile 1 | Tertile 2 | Tertile 3 | P-valuec |
| Grade 4 neutropenia | |||||
| Yes | 115 (72%) | 32 (67%) | 37 (67%) | 46 (81%) | 0.10 |
| No | 45 (28%) | 16(33%) | 18 (33%) | 11 (19%) | |
| Thrombocytopeniab | |||||
| Yes | 115 (73%) | 29 (64%) | 44 (83%) | 42 (71%) | 0.54 |
| No | 42 (27%) | 16(36%) | 9 (17%) | 17 (29%) | |
| Posttreatment hypothyroidism | |||||
| Yes | 23 (17%) | 8 (18%) | 10 (23%) | 5(11%) | 0.35 |
| No | 111 (83%) | 36 (82%) | 34 (77%) | 41 (89%) | |
| 131I-MIBG Monotherapy Protocolsd | |||||
| Grade 4 neutropenia | |||||
| Yes | 80 (71%) | 19 (63%) | 27 (71%) | 34 (77%) | 0.19 |
| No | 32 (29%) | 11 (37%) | 11 (29%) | 10 (23%) | |
| Thrombocytopeniab | |||||
| Yes | 91 (76%) | 22 (71%) | 35 (88%) | 34 (71%) | 0.79 |
| No | 28 (24%) | 9 (29%) | 5 (12%) | 14 (29%) | |
| Posttreatment hypothyroidism | |||||
| Yes | 16(16%) | 4(16%) | 7 (21%) | 5 (12%) | 0.62 |
| No | 82 (84%) | 21 (84%) | 26 (79%) | 35 (88%) | |
a
Lab values unavailable for 53 patients (ANC), 56 patients (platelet count), and 79 patients (TSH/T4);
b
Assessed using a platelet count threshold of 20,000/μl;
c
Cochran–Mantel–Haenszel test;
d
Lab values unavailable for 17 patients (ANC), 10 patients (platelet count), and 31 patients (TSH/T4).