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. Author manuscript; available in PMC: 2020 Sep 29.
Published in final edited form as: Cancer. 2019 Oct 4;126(2):416–424. doi: 10.1002/cncr.32553

TABLE 3.

Marginal Association Between Factors and Care Outcomes

Care Outcome
QOL (PedsQL Score >Median)
Parental Regret
Factor Percentage With High QOL OR (95% CI)a Percentage With Regret OR (95% CI)a

Overall 50 41
Parent characteristics
Male sex 53 1.19 (0.41–3.43) 50 1.09 (0.36–3.32)
Education ≤high school 54 1.20 (0.37–3.89) 56 1.81 (0.63–5.27)
Race/ethnicity
 White 44 Reference 45 Reference
 Black 50 1.26 (0.28–5.60) 13 0.17 (0.02–1.50)
 Hispanic 67 2.52 (0.87–7.27) 33 0.60 (0.21–1.74)
 Other 44 1.01 (0.24–4.19) 56 1.51 (0.36–6.26)
Understanding of prognosis
Recognition of poor prognosis 43 0.66 (0.25–1.72) 46 1.41 (0.55–3.64)
Care experiences
>Median mo between diagnosis and survey 52 1.73 (0.52–5.76) 40 0.77 (0.24–2.51)
>Median prior treatment regimens 52 1.20 (0.52–2.74) 50 2.06 (0.88–4.83)
High medical intensity of care 48 0.84 (0.37–1.92) 55 3.14 (1.31–7.51)
Last treatment regimen caused suffering with limited benefit 10 0.11 (0.01–0.87) 73 4.78 (1.16–19.72)
A great deal/a lot of suffering from pain 16 0.11 (0.03–0.36) 52 1.92 (0.77–4.78)
A great deal/a lot of suffering from any symptom 28 0.11 (0.04–0.29) 51 2.91 (1.18–7.16)
Goals of care
QOL goal 35  0.46 (0.15–1.38) 24  0.39 (0.12–1.33)
Care decisions
Decision for low-intensity or no cancer-directed therapy 60 1.61 (0.62–4.19) 44 1.35 (0.52–3.50)
Care outcomes
PedsQL score >median NA NA 31 0.52 (0.22–1.24)

Abbreviations: NA, not applicable; OR, odds ratio; PedsQL, Pediatric Quality of Life Inventory; QOL, quality of life.

a

Bold type indicates P < .05.