Fig 2. Autism PRS association with PNC phenotypes.

Overview of best-fit models for autism spectrum disorder (ASD) associating with neurodevelopmental phenotypes in adult (AP, N_phenotypes = 324), middle (MP, N_phenotypes = 490), and young (YP, N_phenotypes = 311) probands of the Philadelphia Neurodevelopmental Cohort. (A) Maximum phenotypic variance explained (R²) by the best model fit for each trait given genetic liability to ASD. The dashed horizontal line represents the nominal significance threshold. (B-D) The relationship between binned ASD polygenic risk scores for AP, MP, and YP participants and the most significant phenotype predicted by ASD genetic liability: (B) SIP033 Structural Interview for Prodromal Symptoms: “Has anyone pointed out to you that you are less emotional or connected to people than you used to be?”; (C) PEITANG: Number of correct responses to anger trials during completion of The Penn Emotional Identification Test (PEIT) for recognizing angry emotions; (D) PADT_SAME_PC: Percent of correct responses to test trials with no age difference during completion of the Penn Age Differentiation Test for detecting which face in a face pair appears older. Note the lowest quartile in figures B-D represents the referent.