Table 2. Relationship between PEITANG and PRS of additional phenotypes.

Best model fit PRS of psychiatric disorder, educational attainment, and brain image-derived phenotype polygenic risk scores associated with the PEITANG phenotype in the Philadelphia Neurodevelopmental Cohort middle proband group (aged 11–17 years old).

Trait	Unadjusted for ASD PRS			Adjusted for ASD PRS
	R2 (%)	z-score	p	R2 (%)	z-score	p
Schizophrenia	1.50	6.32	3.12 x 10−10	0.898	4.89	1.05 x 10−6
Attention deficit hyperactivity disorder	0.204	2.32	0.021	0.04	1.03	0.303
Educational attainment	0.463	3.49	4.98 x 10−4	0.233	2.48	0.013
Left cerebellum white matter volume	0.58	3.91	9.62 x 10−5	0.318	2.9	3.35 x 10−4
Mean diffusion tensor mode (MO) in sagittal stratum (left) on FA skeleton (from dMRI data)	0.469	-3.51	4.59 x 10−4	0.333	-2.97	0.003
Mean L1 in anterior limb of internal capsule (right) on FA skeleton (from dMRI data)	0.236	-2.48	0.013	0.167	-2.1	0.037
Mean L3 in uncinate fasciculus (left) on FA skeleton (from dMRI data)	0.286	2.74	0.006	0.269	2.67	0.008
Right hemisphere central sulcus area (from Destrieux Atlas)	0.56	-3.84	1.27 x 10−4	0.428	-3.37	7.64 x 10−4
Left hemisphere cuneus gyrus thickness (from Destrieux Atlas)	0.413	3.29	0.001	0.322	2.92	0.004