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. 2020 Sep 17;16(9):e1008165. doi: 10.1371/journal.pcbi.1008165

Fig 3. Saturation nonlinearities in Model A.

Fig 3

Transfer function (first row) and CV (second row) computed numerically from Eqs (3)(5) and (6) (continuous lines) for different g (first column), C (second column) and J (third column). As in Fig 2, colored dotted lines in the first row represent values of the rates at which umax = − 1. Black dashed lines solutions of the approximated Eqs (13) and (14). This validation of the approximated rate equation motivates the perturbative approach used in the main text and allows to classify nonlinearities in a general way. Simulation parameters: J = 0.2 mV, K = 103 in (A,D); g = 5.0, J = 0.1mV in (B,E); g = 5.0, K = 103 in (C,F); in all plots gX = 1, τ = 20ms.