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Aortic valve function in lean (square, solid line) and obese (triangles, dashed line) ZSF1 rats. (A) Mean aortic valve peak velocity (m/s), (B) mean aortic valve peak pressure gradient (mmHg), and (C) aortic valve opening area (mm2) in 6‐, 10‐, 15‐, 20‐, and 32‐week‐old animals. Representative pulsed‐wave Doppler recordings of ZSF1‐lean (D) and ZSF1‐obese (E) are depicted. Values are shown as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001 vs. ZSF1‐lean.
