TABLE 3.
Echocardiographic parameters at randomization (week 0) and after 12 weeks of nephron blockade or renin‐angiotensin system blockade treatment
| Week 0 | Week 12 | |||||
|---|---|---|---|---|---|---|
| NBD N = 45 | RAS N = 40 | P value | NBD n = 45 | RAS n = 40 | P value | |
| LVED diameter (mm) | 48.3 ± 5.2 | 50.7 ± 4.2 | 0.0244 | 48.4 ± 4.6 | 51.6 ± 5.8 | 0.0059 |
| LVMI (g/m2) | 97.3 ± 17.5 | 98.2 ± 27.6 | 0.854 | 89.1 ± 18.9 | 100.0 ± 24.0 | 0.0246 |
| LVEF (%) | 68.0 ± 8.2 | 66.1 ± 8.5 | 0.299 | 66.9 ± 8.1 | 67.0 ± 7.5 | 0.968 |
| Cardiac output (l/min) | 6.1 ± 1.7 | 5.8 ± 1.4 | 0.529 | 5.8 ± 1.5 | 5.3 ± 1.2 | 0.083 |
| LVED volume (mL/m2) | 65.9 ± 18.7 | 63.6 ± 11.9 | 0.532 | 66.6 ± 17.2 | 66.7 ± 16.6 | 0.977 |
| LVES volume (mL/m2) | 20.9 ± 8.3 | 21.9 ± 7.8 | 0.589 | 22.4 ± 9.6 | 22.2 ± 8.6 | 0.922 |
| TI velocity (cm/s) | 2.46 ± 0.31 | 2.33 ± 0.23 | 0.0476 | 2.35 ± 0.21 | 2.47 ± 0.27 | 0.0327 |
| Left atrial area (cm2) | 17.7 ± 4.2 | 18.5 ± 4.0 | 0.401 | 16.5 ± 3.6 | 19.2 ± 3.9 | 0.0021 |
| Lat e‐wave velocity (cm/s) | 9.0 ± 2.3 | 8.7 ± 3.0 | 0.608 | 9.4 ± 2.3 | 9.1 ± 3.1 | 0.641 |
| Sep e‐wave velocity (cm/s) | 7.0 ± 2.0 | 6.8 ± 1.9 | 0.564 | 7.5 ± 2.3 | 7.3 ± 2.5 | 0.789 |
| E‐wave velocity (cm/s) | 69.9 ± 13.4 | 66.6 ± 15.8 | 0.302 | 67.5 ± 13.1 | 75.8 ± 20.5 | 0.0331 |
| E/é ratio | 9.6 ± 2.5 | 9.6 ± 3.0 | 0.917 | 8.7 ± 2.2 | 10.4 ± 4.3 | 0.0236 |
| Assesment of diastolic function | ||||||
|---|---|---|---|---|---|---|
| NBD n = 32 | RAS n = 31 | P value | NBD n = 32 | RAS n = 31 | P value | |
| Normal, n (%) | 22 | 25 | 0.676 | 31 | 21 | 0.0048 |
| Undetermined, n (%) | 9 | 5 | 1 | 6 | ||
| Diastolic dysfunction, n (%) | 1 | 1 | 0 | 4 | ||
LVEDd, left ventricular end diastolic diameter; LVMI, left ventricular mass index; TI velocity, tricuspid insufficiency velocity.
Full data of echographic parameters for assessment of diastolic function were available in 43% and 46% of subjects in NBD arm and RASB arm, respectively.