Table 5.
Cox univariate and multivariable analyses of factors for predicting mortality
| Univariate | Multivariable a | Multivariable b | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Phenylalanine ≥ 112 μM | 5.06 (2.83–9.05) | <0.001 | 3.09 (1.66–5.76) | <0.001 | 2.57 (1.28–5.16) | <0.001 |
| APACHE II score | 1.08 (1.03–1.13) | 0.002 | ||||
| SOFA score | 1.17 (1.09–1.26) | <0.001 | ||||
| VISmax score | 1.04 (1.03–1.06) | <0.001 | 1.03 (1.01–1.05) | 0.006 | 1.04 (1.02–1.07) | 0.001 |
| Atrial fibrillation | 2.47 (1.36–4.47) | 0.003 | ||||
| CRP (log) | 3.20 (1.82–5.63) | <0.001 | ||||
| Cholesterol (mg/dL) | 0.99 (0.98–0.99) | 0.003 | ||||
| Pre‐albumin (mg/dL) | 0.90 (0.85–0.95) | <0.001 | ||||
| Transferrin (mg/dL) | 0.99 (0.98–0.99) | 0.004 | ||||
| IL‐8 (log) × 10−1 | 1.24 (1.17–1.33) | <0.001 | 1.10 (1.01–1.19) | 0.024 | 1.17 (1.08–1.28) | <0.001 |
| IL‐10 (log) × 10−1 | 1.27 (1.16–1.39) | <0.001 | 1.13 (1.02–1.25) | 0.026 | 1.20 (1.08–1.33) | 0.001 |
APACHE II, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; CRP, C‐reactive protein; HR, hazard ratio; IL, interleukin; SOFA, Sequential Organ Failure Assessment; VISmax, maximal vasoactive–inotropic scores in 24 h after enrolment.
a
Multivariable analysis with forward selection model for all variables with P < 0.05 in the univariate analysis.
b
Adjusted for age, APACHE II score, SOFA score, atrial fibrillation, CRP, cholesterol, pre‐albumin, and transferrin.