Table 3.

Properties of different rat strains.

Rat strain	Properties	Reference
Sprague-Dawley	Widely used outbred rat in biomedical research Good reproductive performance Genetically heterogeneous outbred rodents Albino strain of rats Ease in handling	52
Wistar	The outbred Wistar and Wistar HAN strains are used widely in Europe for preclinical safety assessments Wistar Kyoto and Wistar Furth rats are inbred strains A multipurpose model, i.e., infectious disease research, safety and efficacy testing, fracture models, and aging	53–56
Fischer 344 (F-334)	Previously used in toxicity and carcinogenicity studies In some models, F344 rat carcinogenicity studies lack relevance in predicting human carcinogenicity	57
Lewis (LEW)	Studies rewarding/reinforcing properties of drugs of abuse Impulsive traits Vulnerability to neuroinflammatory disease	58
wild-type Groningen	Studies on aggression and aspects of impulsivity Less vulnerable to social stress during adolescence in comparison to Wistar rats	59,60
BioBreeding rats	Diabetes-prone bio-breeding (DP-BB) rats spontaneously develop type 1 diabetes mellitus	61