Table 3.

Covariates influencing the IM during follow-up of sepsis patients.

Variable	Groups1	Associated OTUs	Influence on associated OTUs2	Top OTUs associated3	p-value
Age	NA	49	4.54	OTU2: g_Klebsiella	0.004
				(2.08)
			(5.10/1.12)	OTU10: g_Prevotella	< 0.001
				(-2.97)
Antibiotic treatment	6 (Carbapenems, Cephalosporins, Glycopeptides, Macrolides, Oxazolidinones, Penicillins)	24	2.38	OTU26: g_Pseudomonas	< 0.001
				(2.24 for Oxazolidinones)
			(4.624/1.94)	OTU122: g_Sutterella (-0.93 for Cephalosporins)	0.004
% caloric intake	NA	17	3.59	OTU150: g_Megasphaera	0.003
			(1.46/0.41)	(-0.50)
Nutritional support	2 (Enteral, Parenteral)	7	8.23	OTU8: s_Bacteroides fragilis	0.003
			(3.99/0.49)	(0.95 for Parenteral)
ICU time	NA	4	4.15	OTU92: f_Christensenellaceae	0.006
				(0.82)	0.008
			(1.57/0.38)	OTU406: g_Sutterella
				(-0.52)
ICU discharge	2 (Alive, Dead)	3	12.93	OTU45: g_Enterococcus	0.006
			(4.91/0.38)	(0.63 for Dead)
Sex	2 (Men/Women)	2	8.39	OTU1070: g_Fusobacterium	0.008
				(0.26 for Women)
			(4.02/0.48)	OTU28: g_Finegoldia	0.004
				(-0.48 for Women)

1 When categorical variables were analyzed, the reference group for comparison is underlined. NA, not available.

2 Ratio obtained from the averaged explained variability of associated OTUs over the averaged explained variability of all OTUs analyzed. Percentages are shown between parentheses.

3 The taxonomy and variance (log-scale) associated with OTUs showing the extreme positive and negative associations with the variable are disclosed when available. The taxonomy assignment was assessed with SINA aligner and the SILVA database. Only reliable identifications based on the last-common-ancestor (lca) approach are presented disclosing family (f_), genus (g_), or species (s_) assignments.

4 Average obtained from different groups when samples were categorized in more than 2.