Figure 6.
Myeloid dendritic cells producing cytokines in response to Gram-negative commensal bacteria promote IFNγ production by Group 1 ILCs. (a) Percentages of IL-12p70+, IL-18+, or IL-1β+ mDCs or macrophages after LPMC exposure to no bacteria control (-), A. junii (Aj) or R. bromii (Rb). N = 4. (b) Percentages of IFNγ+ NK cells or ILC1s after LPMC exposure to A. junii with no depletion control (total LPMCs) or mDC depletion. N = 3. Bars are mean + S.E.M. Statistical analysis performed was one-way ANOVA comparing the mean of each column with the mean of the control column (no bacteria). *p < .05, #p = .0637.