Figure 7.

NLRP3 deficiency partially counteracted the gut microbiota dysbiosis induced by AP. (a) Alpha diversity, as revealed by the Shannon index, was analyzed in WT and NLRP3 KO mice with or without AP challenge. *p < .05, **p < .01. (b) Principal coordinate analysis (PCoA) of bacterial beta diversity based on the unweighted UniFrac distance. Samples from the AP group clustered distinctly from those of the control group in WT mice, while samples from NLRP3 KO mice converged together independent of AP induction. (c) Relative abundance of the top 5 phyla in WT and NLRP3 KO mice at baseline. (d) Linear discriminant analysis (LDA) scores were computed for features (at the genus level) that were differentially abundant between the WT and NLRP3 KO groups without treatment. (e) Alterations in the top 5 most abundant phyla between WT and NLRP3 KO mice after AP induction. (f) LEfSe analysis identified the most differentially abundant genera between WT and NLRP3 KO mice with AP.