Table 3.
Signs and symptoms of ETEC following challenge with 1.7 to 1.5 × 1010 colony forming units of strain B7A.
| Group |
|||
|---|---|---|---|
| Placebo (n = 20) |
Anti-CS6 (n = 19) |
Anti-B7A (n = 20) |
|
| Moderate-Severe Diarrhea (%) | 70.0 | 63.2 | 35.0a |
| Abdominal distension (%) | 45.0 | 10.5b | 10.0b |
| Abdominal pain (%) | 60.0 | 63.2 | 35.0 |
| Abdominal tenderness (%) | 35.0 | 26.3 | 0.0b |
| Arthralgia (%) | 25.0 | 10.5 | 0.0b |
| Chills (%) | 25.0 | 36.8 | 0.0b |
| Decreased appetite (%) | 50.0 | 52.6 | 20.0 |
| Headache (%) | 50.0 | 36.8 | 20.0 |
| Malaise (%) | 45.0 | 42.1 | 5.0b |
| Myalgia (%) | 30.0 | 31.6 | 15.0 |
| Nausea (%) | 55.0 | 63.2 | 0.0b |
| Fever (%) | 0.0 | 10.5 | 5.0 |
| Vomiting (%) | 25.0 | 15.8 | 5.0 |
| Median (Q1, Q3) maximum 24 hr loose stool weight (g) | 483.5 (110.0, 929.5) |
451.0 (92.0, 879.0) |
349.5 (0.0, 634.0) |
| Median (Q1, Q3) maximum 24 hr loose stool frequency | 4.0 (1.0, 7.5) |
4.0 (1.0, 8.0) |
2.0 (0.0, 5.0) |
| Median (Q1, Q3) total loose stool output weight (g) | 745.5 (309.0, 1371.0) |
764.5 (340.0, 1160.0) |
659.0 (297.0, 1154.0) |
| Median (Q1, Q3) total frequency of loose stools | 7.5 (2.0, 10.0) |
5.5 (2.0, 13.0) |
4.0 (3.0, 12.0) |
| Median (Q1, Q3) ETEC disease severity | 4.0 (2.0, 5.5) | 4.0, (3.0, 5.0) | 3.0 (1.0, 3.5)c |
ap < 0.05 compared to placebo (based on a 1-sided Fisher’s Exact test).
b p < 0.05 compared to placebo (based on a 2-sided Fisher’s Exact test).
c p < 0.05 compared to placebo (based on a 2-sided Kruskal-Wallis test).