Table 2.
Primary Screening Algorithms for the Detection of CIN2+/CIN3+, % (95% CI)
| Primary Screening | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| CIN2+ | ||||
| hrHPV+ | 96.4 (89.1–99.1) | 76.8 (74.2–79.3) ** | 28.2 (25.7–30.9) | 71.8 (69.1–74.3) |
| HPV 16/18+ | 41.0 (30.5–52.3) ** | 92.4 (90.6–93.8) ** | 9.9 (8.3–11.8) | 90.1 (88.2–91.7) |
| Cytology ≥ASC-US | 90.4 (81.4–95.4) | 71.8 (69.1–74.4) ** | 32.5 (29.9–35.2) | 67.5 (64.8–70.1) |
| Cytology ≥ LSIL | 72.3 (61.2–81.3) * | 87.3 (85.1–89.1) | 16.9 (14.8–19.1) | 83.1 (80.9–85.2) |
| p16+ | 86.7 (77.1–92.9) | 87.7 (85.6–89.5) | 17.5 (15.4–19.8) | 82.5 (80.2–84.6) |
| CIN3+ | ||||
| hrHPV+ | 95.1 (82.2–99.2) | 74.1 (71.5–76.6) ** | 28.2 (25.7–30.9) | 71.8 (69.1–74.3) |
| HPV 16/18+ | 48.8 (33.2–64.6) ** | 91.4 (89.6–93.0) ** | 9.9 (8.3–11.8) | 90.1 (88.2–91.7) |
| Cytology ≥ASC-US | 97.6 (85.6–99.9) | 69.8 (67.1–72.4) ** | 32.5 (29.9–35.2) | 67.5 (64.8–70.1) |
| Cytology ≥ LSIL | 90.2 (75.9–96.8) | 85.7 (83.5–87.7) | 16.9 (14.8–19.1) | 83.1 (80.9–85.2) |
| p16+ | 95.1 (82.2–99.2) | 85.3 (83.1–87.3) | 17.5 (15.4–19.8) | 82.5 (80.2–84.6) |
Notes: Significant McNemar’s Test comparing to p16 staining *P<0.05. **P<0.001
Abbreviations: LSIL, low-grade squamous intraepithelial lesions; ASC-US, atypical squamous cells of undetermined significance; CIN2+/CIN3+, cervical intraepithelial neoplasia 2/3 or worse; CI, confidence interval; hrHPV, high-risk HPV; PPV, positive predictive value; NPV, negative predictive value.