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. 2020 Sep 25;13:3371–3381. doi: 10.2147/DMSO.S274534

Figure 1.

Figure 1

Basic Research on TCM in the Treatment of Obesity. The three pathways of TCM in obesity treatment to: 1. By affecting the composition of intestinal microflora, regulation of intestinal metabolites (SCFAs, bile acids, and BACC) directly affects the roles of metabolites in obesity or indirectly increases the secretion of hormones by endocrine cells (GLP-1, PYY, and CKK) that regulate the hypothalamus, affect appetite and attenuate obesity. 2. AMPK is activated to regulate lipid metabolism or upregulate BAT-related genes in WAT to promote the browning of WAT and thermogenic fat activation. 3. Directly or indirectly promote fat tissue secretion of leptin, adiponectin, FGF21, GLP-1, and PYY to promote lipid metabolism and/or affect appetite by regulating the hypothalamus.