Table 2.

Top 10 selected significantly enriched gene sets in coronary artery disease patients with heart failure

ES	Reactome ID (R‐HSA)	Reactome description	n	P‐value	FDR q‐value	Key gene pathway area and function
−0.39	72187	mRNA processing	50	<0.0001	<0.0001	Metabolism of RNA: mRNA splicing and transport
−0.35	159236	mRNA transport	68	<0.0001	<0.0001	Metabolism of RNA: mature RNA transport via nuclear pore complex
−0.31	3214841	Methylation of histones	42	<0.0001	0.0005	Chromatin organization: methylation of lysine 5 of histone H3
−0.59	390666	Serotonin receptors	10	0.002	0.01	Signal transduction: 5‐HT1 and 5‐HT5A receptors that bind serotonin
−0.38	264876	Insulin processing	24	<0.0001	0.01	Metabolism of proteins: translocation of insulin secretory granules
0.30	381070	Activates chaperones	50	<0.0001	0.008	Metabolism of proteins: unfolded protein response in the endoplasmic reticulum
0.42	449836	Other interleukins	23	<0.0001	0.011	Immune system: interleukin signalling: IL‐34, IL‐32, and CD4
0.33	2029481	FC gamma receptor activation	38	<0.0001	0.015	Innate immunity: FCGR‐dependent phagocytosis: immunoglobulin light chains
0.39	5576893	Plateau phase	25	<0.0001	0.018	Cardiac conduction: calcium transport
0.33	445355	Smooth muscle contraction	33	0.02	0.025	Muscle contraction: tropomysin 2 and myosin light chains

ES, enrichment score (negative: reduced promoter methylation; positive: increased promoter methylation); FDR: false discovery rate; n, number of genes in the gene set.