Table 1.
Characteristics of the study population.
| Characteristic | Healthy (n = 76) |
NASH (n = 40) |
NASH-cirrhosis (n = 25) |
|---|---|---|---|
| Sex (female/male) | 67/9 | 20/20 | 15/10 |
| Mean age (mean±SEM) | 66.3 ± 1.06 | 60.3 ± 1.6a | 64.0 ± 2.0 |
| Mean BMI (kg/m2, mean±SEM) | 26.5 ± 0.5 | 34.9 ± 1.1a | 34.0 ± 1.1b |
| Type 2 Diabetes | 0 | 22a | 19b |
| Hypertension | 1 | 19a | 14b |
| Shannon diversity (mean±SEM) | 5.83 ± 0.1 | 5.32 ± 0.1a | 5.18 ± 0.2b |
| Observed OTUs (mean±SEM) | 405.3 ± 10.9 | 334.8 ± 9.5a | 313.7 ± 16.9b |
NASH: nonalcoholic steatohepatitis; SEM: standard error of the mean; OTUs: operational taxonomic unit.ap < .05 Healthy vs NASH, bp < .05, Healthy vs NASH-cirrhosis, cp < .05 NASH vs NASH-cirrhosis, ANOVA with a priori contrasts or Kruskal–Wallace followed by Mann–Whitney U test as appropriate based on distribution.