Table 3.
Multivariable Cox Regression for Enterobacteriaceae Bacteriuria and Enterobacteriaceae UTI. Univariate Cox regression analysis was performed for each of the characteristics and the development of Enterobacteriaceae bacteriuria or Enterobacteriaceae UTI. The combined relative abundance of Faecalibacterium and Romboutsia (cutoff of 13.8%) was analyzed as a time-dependent covariate and first antibiotic administration was analyzed as a time-dependent covariate. For characteristics that were significantly associated with either Enterobacteriaceae bacteriuria or Enterobacteriaceae UTI (P < .10), a multivariable Cox Regression was performed with the significantly associated characteristics. Table 3A. Multivariable Cox Regression for Enterobacteriaceae bacteriuria. Table 3B. Multivariable Cox Regression for Enterobacteriaceae UTI. ESRD, end stage renal disease; DM, diabetes mellitus; HTN, hypertension; PRA panel reactive antibody; PCP, Pneumocystis jiroveci.
| Table 3A | ||||||||
| Risk Factors for Enterobacteriaceae UTI |
Univariate Analysis |
|
Multivariate Analysis |
|
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| Characteristic | HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Age, Years | 1.0 (1.0–1.0) | 0.54 | ||||||
| Female Gender | 4.1 (2.2–7.6) | 6.8 x 10−6 | 4.4 (2.3–8.2) | 3.9 x 10−6 | ||||
| African American Race | 0.9 (0.4–1.6) | 0.65 | ||||||
| History of Diabetes Mellitus | 1.4 (0.8–2.4) | 0.29 | ||||||
| Cause of ESRD – DM | 1.4 (0.8–2.5) | 0.29 | ||||||
| Cause of ESRD – HTN | 0.9 (0.4–2.1) | 0.82 | ||||||
| PRA ≥ 80% | 1.1 (0.4–2.8) | 0.81 | ||||||
| Decreased Donor Transplantation | 1.2 (0.7–2.2) | 0.49 | ||||||
| Delayed Graft Function | 1.2 (0.6–2.5) | 0.53 | ||||||
| Cefazolin Preoperative Abx | 0.5 (0.2–0.9) | 0.01 | 0.5 (0.2–0.9) | 0.02 | ||||
| Trimethoprim/Sulfamethoxazole PCP Prophylaxis | 3.2 (0.4–23.2) | 0.25 | ||||||
| Anti-thymocyte Globulin Induction | 1.1 (0.6–2.1) | 0.82 | ||||||
| Prednisone Maintenance | 1.3 (0.7–2.4) | 0.34 | ||||||
| First Antibiotic Administration | 2.1 (1.1–3.8) | 0.02 | 1.4 (0.7–2.6) | 0.33 | ||||
| Relative Abundance of Faecalibacterium & Romboutsia |
0.2 (0.1–0.7) |
0.008 |
0.3 (0.1–0.8) |
0.02 |
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| Table 3B | ||||||||
| Risk Factors for Enterobacteriaceae UTI |
Univariate Analysis |
|
Multivariate Analysis |
|
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| Characteristic | HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Age, Years | 1.0 (1.0–1.0) | 0.31 | ||||||
| Female Gender | 4.4 (2.0–9.7) | 2.8 x 10–4 | 4.4 (2.0–9.9) | 3.2 x 10–4 | ||||
| African American Race | 0.8 (0.3–1.8) | 0.55 | ||||||
| History of Diabetes Mellitus | 1.3 (0.7–2.7) | 0.44 | ||||||
| Cause of ESRD – DM | 1.2 (0.6–2.5) | 0.60 | ||||||
| Cause of ESRD – HTN | 0.5 (0.2–1.9) | 0.33 | ||||||
| PRA ≥ 80% | 0.7 (0.2–3.0) | 0.63 | ||||||
| Decreased Donor Transplantation | 1.1 (0.5–2.2) | 0.88 | ||||||
| Delayed Graft Function | 0.9 (0.3–2.3) | 0.80 | ||||||
| Cefazolin Preoperative Abx | 0.5 (0.2–1.1) | 0.07 | 0.5 (0.2–1.2) | 0.12 | ||||
| Trimethoprim/Sulfamethoxazole PCP Prophylaxis | – – | – – | ||||||
| Anti-thymocyte Globulin Induction | 1.0 (0.5–2.3) | 0.95 | ||||||
| Prednisone Maintenance | 1.0 (0.5–2.1) | 0.99 | ||||||
| First Antibiotic Administration | 2.2 (1.1–4.7) | 0.03 | 1.5 (0.7–3.3) | 0.29 | ||||
| Relative Abundance of Faecalibacterium & Romboutsia | 0.3 (0.1–0.9) | 0.04 | 0.4 (0.1–1.2) | 0.09 | ||||