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Development of hard capsules for oral administration of freeze-dried fecal microbiota. Upper panel: (a) examples of macroscopic aspects (n = 4). (b) microscopic aspects Optical Microscopy (x10) and (c) SEM. Lowe panel: flowability and bulk density of FD samples without excipient (n = 5), with 25% to 75% filler (n = 2) or with glidant (G1 n = 1, G2 n = 1, G3 n = 6), ND: not determined.
