Figure 3.

Determinants of neonates gut microbiota composition and the effects of microbiota composition on neonatal growth.

(a) Forest plot visualizes the association of meconium microbiota composition with neonatal growth in ART and spontaneous conception groups. Linear regression models were fitted to assess the associations of α-diversity and Bacteroidetes phylum relative abundance with birth weight, weight gain rate during the first 42 days and 6 months of life. (b) Structural Equation Modeling showed that in ART pregnancies, the usage of vaginal suppositories for luteal phase support were independently associated with Bacteroidetes abundance in neonates. Bacteroidetes abundance was inversely associated with weight gain rate. Estimated β coefficients are reported. CFI, comparative fix index; RSMEA, root-mean-square error of approximation; SRMR, standardized root-mean residuals; *P < .05, **P < .01, ***P < .001. Green line represents inverse association; red line represents positive associations.