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. 2020 Sep 6;12(1):1800897. doi: 10.1080/19490976.2020.1800897

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — (a) Alpha-diversity in patients’ stool microbiome, represented by the Shannon index and Chao-1 index, before induction (T0), during aplasia (T1) and after hematological recovery (T2). p < .05 is considered significant. (b) A subset of OTUs, grouped by family, with a raw count at least of 300 was kept. Bray-Curtis distance and UPGMA algorithm were used to perform pairwise distance between samples and hierarchical clustering, respectively. The heatmap highlighted a clustering of two groups dominated by Bifidobacteriaceae, Lachnospiraceae and Ruminococcaceae at T0 progressively replaced by Enterococcaceae or Enterobacteriaceae at T1 and T2.