Table 1.
Characteristics at the Start of GnRHa Treatment and at the Start of Gender-Affirming Hormone Treatment
| Start GnRHa | Transgirls (n = 51) | Transboys (n = 70) | P value | |
|---|---|---|---|---|
| Age in years, mean ± SD | 14.1 ± 1.7 | 14.5 ± 2.0 | n.s. | |
| Pubertal group: Early/late | 15/36 | 14/56 | n.s. | |
| Height in cm, mean ± SD | 169.0 ± 8.9 | 162.2 ± 8.8 | <0.001 | |
| Weight in kg, mean ± SD | 57.9 ± 12.9 | 56.2 ± 14.7 | n.s. | |
| BMI in kg/m2, mean ± SD | 20.1 ± 3.3 | 21.3 ± 4.2 | n.s. | |
| Serum estradiol in pmol/L, median [IQR] | Early: 113.5 [63.5–129.3] | |||
| Late: 121 [83.5–231.5] | ||||
| Serum testosterone in nmol/L, median [IQR] | Early: 3.8 [2.15–6.15] Late: 13 [10.3–17.8] | |||
| Start gender-affirming hormones | Transgirls (n = 36) | Transboys (n = 42) | ||
| Age in years, mean ± SD | 16.2 ± 1.2 | 16.9 ± 1.1 | 0.005 | |
| Pubertal group: Early/late | 10/26 | 5/37 | n.s. | |
| Duration of GnRHa use before start GAH, years | 2.0 ± (0.94) | 1.8 ± (1.11) | n.s. | |
| Height in cm, mean ± SD | 176.5 ± 7.3 | 167.1 ± 7.4 | 0.005 | |
| Weight in kg, mean ± SD | 66.7 ± 11.9 | 63.5 ± 11.5 | n.s. | |
| BMI in kg/m2, mean ± SD | 21.1 ± 3.2 | 22.8 ± 4.0 | n.s. |
Abbreviations: BMI, body mass index; GAH, gender-affirming hormones; GnRHa, gonadotropin-releasing hormone analogue; IQR, interquartile range; n.s., not significant; SD, standard deviation.