Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 14;12(1):1785803. doi: 10.1080/19490976.2020.1785803

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — Tumor development with AOM/DSS in mice and recovery of the AOM/DSS-induced colitis-associated colorectal cancer (CAC) mouse model with L. gasseri 505 (LG), C. tricuspidata leaf extract (CT), and fermented CT by L. gasseri 505 (FCT). (a) Experimental procedure for development of the AOM/DSS-induced CAC model and sample (LG, CT, or FCT) administration. Mice were given a single intraperitoneal (i.p.) injection of AOM (10 mg/kg) and then received 2.5% DSS in the drinking water for one week, followed by two weeks of regular drinking water for recovery; this treatment cycle was repeated three times. The sample (LG, CT, or FCT) was administered orally in the CAC mice for 10 weeks. (b) Change of average body weight (g) of the mice in the groups; control mouse (Con), AOM-DSS-induced CAC mouse (AOM/DSS), LG, CT, and FCT. (c) A photograph for measuring and comparing colon lengths of the groups at Week 11. (d) A graph of average colon lengths in the groups at Week 11. (e) Occurrence of colon tumors in the groups. The data present the mean ± standard deviation (SD). Asterisks denote significance vs. AOM/DSS group by one-way ANOVA (*p < .05, **p < .01, ***p < .001). (f) H&E staining of representative histological sections of colons from the groups (200 × magnification).