Table 1.
Characteristics of the recruited dogs according to disease status and cluster.
| HC dogs (n = 8, 38 samples) | CAF dogs (n = 12, 70 samples) | CAF dogs, near cluster (n = 7, 65 samples) | CAF dogs, far cluster (n = 5, 43 samples) | |
|---|---|---|---|---|
| Dogs description | ||||
| Average age (years) ± STDEV | 7.3 ± 1.43 | 4.3 ± 1.28 | 7.9 ± 1.53 | 7 ± 0.89 |
| Average weight (kg) ± STDEV | 36.9 ± 7.93 | 41.1 ± 7.31 | 42.4 ± 9.37 | 39.2 ± 2.77 |
| Female sex | 4 (50%) | 3 (25%) | 1 (14.3%) | 2 (40%) |
| Number of fistulas | ||||
| 0–2 | 0 | 4 | 3 | 1 |
| 3–5 | 0 | 5 | 3 | 2 |
| >5 | 0 | 3 | 0 | 3 |
| Pathology findings | ||||
| Morphological features | ND | |||
| Crypt hyperplasia | 3 (25%) | 1 (14.3%) | 2 (40%) | |
| Crypt dilation/distortion (% positive) | 8 (66.7%) | 5 (71.4%) | 3 (60%) | |
| Fibrosis/atrophy (% positive) | 8 (66.7%) | 5 (71.4%) | 3 (60%) | |
| Inflammation | ND | |||
| Lamina Propria lymphocytes and plasma cells (% positive) | 3 (25%) | 1 (14.3%) | 2 (40%) | |
| Lamina Propria Eosinophils (% positive) | 4 (33.3%) | 2 (28.6%) | 2 (40%) | |
| Final diagnosis | ND | |||
| Normal mucosal (% positive) | 3 (25%) | 2 (28.6%) | 1 (20%) | |
| Lymphoplasmatic inflammatory (% positive) |
2 (16.7%) | 0 | 2 (40%) | |
| Eosinophilic inflammatory (% positive) | 4 (33.3%) | 2 (28.6%) | 2 (40%) | |
| Mucosal atrophy/fibrosis (non-inflammatory) (% positive) |
5 (41.7%) | 3 (42.9%) | 2 (40%) |