Record numbers
Total articles from search	6592
Duplicates removed	1499
Remaining records for screening	5093
Title and abstract exclusion
Animal/in vitro studies	118
Studies in children	15
Conference abstracts	11
Studies on other cattle’s product (e.g. donkey, sheep, goat)	68
Studies on human milk	116
Studies on infants and infant formulae	69
Not in English	2
Off topic	4598
Review articles	44
Not RCTs	22
Total ineligible studies	5063
Records available for full text assessment	30
Full text assessment
Full text not available or not in English	5
Comparator not complying with study criteria	14
Wrong study	3
Total ineligible studies	22
Full text included in analysis	8