Figure 3.

Increased abundance of Enterobacteriaceae is associated with disease. (a) Relative abundance of bacterial families Enterobacteriaceae, Acutalibacteraceae and Muribaculaceae across each experiment, before and after transplant. (b) Multivariate sparse partial least squares discriminant analysis (sPLS-DA) based on read mapping to genome database composed of recovered MAGs plus genomes from NCBI (see methods) of post-transplant WT mice. (c) Genome-based signature contributing to component 1 of (B). Genomes with frequency >0.75 across validation replicates displayed. Color indicates group in which median genome abundance is highest. Bar length corresponds to loading weight. CH: cohoused, SH: separately housed.