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. 2020 Jun 26;12(1):1782157. doi: 10.1080/19490976.2020.1782157

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — Serum cytokeratin 18 (CK18-M65) as a surrogate marker of liver damage.

High serum CK18-M65 levels characterized progressive ALD (upper) and differentiate severe forms of alcoholic liver disease from the non-progressive forms of alcoholic liver disease, as shown by Receiver Operating Characteristic (ROC) analysis (middle) (AUROC = 0.8767; 95% CI: 0.7983–0.9551; p < .0001). Below, the cutoff identified using the Youden’s statistics (416.2 U/L) was characterized by high sensitivity and specificity (77.14% and 85.71%, respectively).