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. 2020 Mar 5;11(4):944–961. doi: 10.1080/19490976.2020.1730149

Figure 2.

Figure 2.

Dietary cellulose protected mice against DSS-induced colitis. (a) Scheme of diet and DSS treatment. Eight-week-old female mice were fed a normal chow diet (NCD) or LCD or HCD for 8 weeks and then DSS (2.5%) for 7 days. (b) Body weight and (c) disease activity index (DAI) scores were measured daily (n = 10/group). (d) Colon length was measured at the end of the experiment (n = 10/group). (e) Representative images of H&E- and PAS-stained sections of whole colon. Bar = 1000 μm and 200 μm. (f) Histologic scores for severity of inflammation, extent of injury, crypt damage, and colonic mucin (n = 5 ~ 8/group). (g) Mucin content in colonic crypts measured in PAS-stained slides (n = 5/group). Data are representative of two independent experiments and shown as mean ± SEM. Statistical analyses were conducted using Student’s t-test and one- or two-way ANOVA with Bonferroni’s post-hoc test. Statistical comparisons between NCD-DSS vs. HCD-DSS are represented as ++P < .01, LCD-DSS vs HCD-DSS as $$P < .01, and NCD-DSS vs. LCD-DSS as #P < .05; ##P < .01; **P < .01.