Table 2.

OR, AUC, sensitivity, and specificity of screening algorithms for the exclusion of MIS-C among pediatric patients presenting to the PED

Algorithm	OR	95% CI	AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	Age# OR (95% CI)
A. CDC clinical criteria⁎ met plus composite laboratory criteria 1§	17.44	3.67–82.75	0.81 (0.69–0.92)	0.78 (0.72–0.84)	0.83 (0.62–1.00)	0.86 (0.76–0.97)
B. Institutional clinical criteria¥ met plus composite laboratory criteria 2^	19.65	5.35–72.08	0.78 (0.65–0.93)	0.91 (0.87–0.95)	0.67 (0.40–0.93)	0.87 (0.77–0.99)
C. CDC clinical criteria⁎ met plus compisite laboratory criteria 2^	60.71	12.10–304.66	0.88 (0.77–0.99)	0.92 (0.89–0.96)	0.83 (0.62–1.00)	0.91 (0.79–1.04)
D. Institutional clinical criteria¥ met plus composite laboratory criteria 1§	5.83	1.68–20.25	0.71 (0.56–0.85)	0.74 (0.68–0.81)	0.67 (0.40–0.93)	0.84 (0.75–0.95)

Abbreviations: AUC, area under the curve; CDC, Centers for Disease Control and Prevention; CI, confidence interval; CRP, c-reactive protein; PED, pediatric emergency department; MIS-C, multisystem inflammatory syndrome in children; OR, odds ratio.

^⁎CDC clinical criteria defined as fever ≥24 h plus ≥2 systems involved at the time of PED presentation.

^§Lab criteria 1: CRP & high-sensitivity Troponin I & ferritin all above cut-points, defined as CRP ≥ 87.5 mg/L; troponin I ≥ 17 ng/L; ferritin ≥121.6 ng/mL.

^¥Institutional clinical criteria defined as fever ≥48 h plus one of the following: gastrointestinal features (abdominal pain, vomiting, diarrhea), mucocutaneous features (rash, conjunctivitis, erythema of oral/pharyngeal mucosa), or lymphadenopathy.

^{^}Lab criteria 2: [CRP & d-dimer & ferritin] OR troponin I above the optimal cut-point, defined as CRP ≥ 87.5 mg/L; troponin I, high sensitivity ≥17 ng/L; ferritin ≥121.6 ng/mL; d-dimer ≥1.07 mg/L fibrinogen equivalent units (FEU).

^#Effect per 1 year increase in age when added to corresponding clinical/laboratory model.