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. 2020 Sep 21;130(10):5461–5476. doi: 10.1172/JCI136928

Figure 1. S1PR4 ablation delays mammary tumor progression and reduces lung metastasis.

Figure 1

S1PR4-KO and WT mice were crossed into the polyoma middle T oncogene (PyMT) background. (A) Tumor burden at the endpoint (after 1 tumor reached a diameter of approximately 1.5 cm). (B) Kaplan-Meier curve showing survival of WT (n = 26) and S1PR4-KO PyMT mice (n = 34) until the endpoint. (C) Representative sections of lung lobes stained with Mayer’s hemalum. Arrows indicate metastases. Scale bars: 1 mm. (D) Number of metastatic lung nodules in WT (n = 11) and S1PR4-KO PyMT mice (n = 15) at the endpoint. Means ± SEM; 2-tailed Student’s t test; *P < 0.05, **P < 0.01.