Figure 10. Proposed mechanism of WMI induced by nonlethal IH stress.

(A) The potential relevance of the reported (cell-lethal) paradigms of IH (27–29) inducing WMI and the used (cell-nonlethal) IH model of diffuse WMI to the outcomes and severity (the length of hypoxemia, % of time spent with SpO₂ < 85%, a day) of IH in human premature infants (adapted from Poets et al., ref. 15). (B) Representative ion conductance recorded in mitochondria isolated from the cortex in normoxic mice and the mice subjected to sublethal IH. (C) Schematic illustration of the proposed mechanism for OL maturation failure and diffuse hypomyelination driven by mild, sublethal IH stress in premature infants. ∑, energy.