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. 2020 Aug 31;130(10):5287–5301. doi: 10.1172/JCI135859

Figure 3. Echocardiogram analysis showing RV-specific abnormalities in the p38-cdKO mouse hearts.

Figure 3

(A–C) Serial echocardiographic measurements of (A) end-diastolic RV wall thickness, (B) RV inner diameter, and (C) peak velocity at the pulmonary artery (PA) in the control and p38-cdKO mouse hearts at different perinatal and postnatal time points as indicated (control n = 16, p38-cdKO n = 12 at P1 [D1]; control n = 17, p38-cdKO n = 12 at P3 [D3]; control n = 20, p38-cdKO n = 10 at P7 [D7]; control n = 8, p38-cdKO n = 5 at 1 month; control n = 11, p38-cdKO n = 7 at 4 months; control n = 10, p38-cdKO n = 6 at 8 months; mean ± SEM). (D–F) LV echocardiogram parameters include (D) end-diastolic LV inner chamber diameter, (E) end-diastolic LV wall thickness, and (F) fractional shortening (FS) in the postnatal hearts (control n = 8, p38-cdKO n = 5 at 1 month; control n = 14, p38-cdKO n = 10 at 4 months; control n = 10, p38-cdKO n = 6 at 8 months; mean ± SEM). (G–I) Pulmonary circulation indicators are (G) pulmonary artery acceleration time (PAT), (H) pulmonary ejection time (PET), and (I) PAT/PET ratio in the postnatal hearts (control n = 8, p38-cdKO n = 5 at 1 month; control n = 14, p38-cdKO n = 10 at 4 months; control n = 10, p38-cdKO n = 6 at 8 months; mean ± SEM). (J–L) RV free wall (J), LV free wall (K), and lung (L) weight to body weight ratios at 4 and 8 months (control n = 17, p38-cdKO n = 13 at 4 months; control n = 20, p38-cdKO n = 12 at 8 months; mean ± SEM). ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05 for all panels (control vs. p38-cdKO).