Figure 4. Differences in fold change in circulating proteins between scar-positive and scar-negative individuals.

(A) Significant differences in fold changes in circulating proteins (significantly different in the entire cohort after FDR < 0.05 correction) between scar-positive (n = 290) and scar-negative (n = 15) individuals 90 days after vaccination. Fold changes higher than 1 depicted on a red scale, fold changes lower than 1 depicted on a blue scale. P < 0.05 by Wilcoxon’s matched-pairs signed-rank test. (B) SIRT2 was plotted as an example of a protein that is significantly lower in scar-positive individuals 3 months after BCG vaccination.