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. 2020 Aug 24;130(10):5157–5170. doi: 10.1172/JCI135557

Figure 1. NK-specific killing of WITO-infected CD4+ T cells measured after culture with NK cells and mAbs for 2, 3, 4, or 6 hours or overnight.

Figure 1

NK-specific killing mediated by each antibody was tested using a primary in vitro autologous model, in which NL-LucR.WITO.ecto–infected primary CD4+ T cells were used as targets (T) and autologous purified and IL-15–stimulated NK cells as effectors (E). The percentage specific killing is reported on the y axes and the mAb dilutions on the x axes. Blue, red, purple, black, and green titration curves represent killing at 2, 3, 4, and 6 hours and overnight, respectively. CH65 (an anti-influenza monoclonal antibody) was used as negative control (83). The results show the average of 2 replicates from a single experiment.