Figure 3.

Perturbance of Energy Metabolism, Mitochondrial Dynamics, and Mitochondrial Anti-viral Signaling due to SARS-Coronavirus Infection

SARS-coronavirus infection is believed to induce mitochondrial dysfunction, resulting in oxidative phosphorylation (OXPHOS) deficits, the production of mtROS, dysregulated mitochondrial dynamics, and compromised mitochondrial anti-viral signaling. In combination with hypoxemia it may change cellular bioenergetics, favoring glycolysis over OXPHOS. In summary the new cellular conditions promote viral replication.