Table 3.

Estimated model risk thresholds (5-year risk) identifying highest-risk individuals at equivalent numbers as with the NLST/USPSTF eligibility criteria, in study populations in Germany (GEDA, EPIC), USA and Australia

Study	PLCOM2012	LCRAT	LLP52008	BACH
GEDAa 2008–2013 (55–74 years)	1.46	1.98	2.74	2.20
GEDAa 2008–2013 (50–74 years)	1.52	2.03	2.74	2.27
GEDAa 2008–2013 (50–79 years)	1.75	2.32	3.85	2.49
EPIC-Db 1992–2009 (40–69 years)	2.11	1.61	1.53	1.55
PLCO-CXRc 19 (ever smoker age 55–74 years)	1.12		1.48	1.32
AARPd (ever smoker age 50–71 years)	2.00	2.00		2.00
CPS-IIe (ever smoker age 40–92)	2.00	2.00		2.00
45-upf (age 55–74 years)	1.44
NHISg (1997–2001) survey (ever smoker age 50–80 years)		1.90
NHISg (2010–2012) survey (ever smoker age 50–80 years)	1.67	2.00		2.40

Findings from our analysis in GEDA-data and as reported for other data from the literature, if necessary standardized to 5-year risk

^aGesundheit in Deutschland aktuell [20]

^bEuropean Prospective Investigation into Cancer and Nutrition, Germany (Deutschland) [14]

^cProstate, Lung, Colorectal, and Ovarian Cancer Screening Trial–chest-radiography screening group [12, 16]

^dNIH-AARP (formally known as the American Association of Retired Persons Study of Diet and Health, US-American National Institute of Health) [15]

^eCancer Prevention Study 2 [15]

^f45-up [13]

^eNational Health Interview Survey [15, 26]