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. 2020 Sep 26;12(9):1023–1031. doi: 10.4252/wjsc.v12.i9.1023

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Acquisition of a large number of periodontal ligament stem cells. The illustration shows that the reprogramming of periodontal ligament cells with semaphorin 3A or mesoderm-specific transcript, or differentiation induction of induced pluripotent stem cells to human periodontal ligament stem cell lineage are promising to acquire a large number of periodontal ligament stem cells. iPS cells: Induced pluripotent stem cells; PDLSCs: Periodontal ligament stem cells. Sema3a: Semaphorin 3A; MEST: Mesoderm-specific transcript.