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. 2020 Sep 29;10:15996. doi: 10.1038/s41598-020-73033-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ChemRICH set enrichment statistics diagram. Each disc reflects a significantly altered family of metabolites. Enrichment p-values are given by the Kolmogorov–Smirnov test. Disc sizes represent the total number of metabolites in each group set. Red discs present Increased metabolites while blue ones show decreased compounds in NoDCS rats compared to DCS rats. Intermediates color have both increased and decreased metabolites. For example, there are fewer amino-acids in the feces of NoDCS rats, which is to say that there are more in DCS rats. Insert: volcano plot showing the metabolic dys-regulation in rats exposed to a provocative dive, detailing which of the most significantly altered metabolites were not mapped to metabolic pathways.