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. 2020 Sep 29;10:15958. doi: 10.1038/s41598-020-72531-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Subject-specific, muscle-level response to exosuit. Depicted are the changes in fatigue rate (MDF slope) for individual muscles when receiving exosuit assistance as compared to not receiving assistance (Case I: A1 vs. B). Significant decreases (and increases) in MDF slope with the exosuit are denoted by green (and blue-hatched) shading, where darker shades indicate larger magnitudes of change. Non-significant changes are denoted by light gray shading. The degree to which individual muscles experienced significant reductions in fatigue varied from subject to subject, with one showing significant reductions for all muscles (e.g., subject 1) and others showing significant reductions for a subset (e.g., subject 2). Shading is based on the analysis of covariance results, which were very similar to visual inspection. These responses highlight the variability across individual subjects, as well as the variability across the individual muscles of a single subject, demonstrating that there are multiple ways a wearer can adapt to and benefit from the exosuit.