Table 1.

Body and Organ Weights

	CD	HFHS	HFHS/VAL	HFHS/SAC/VAL	p Value
Body weight, g	37.4 ± 2.0	49.6 ± 1.5‡	49.5 ± 2.4‡	51.0 ± 1.6‡	<0.001
TL, mm	17.2 ± 0.8	17.7 ± 0.8	17.7 ± 0.8	17.5 ± 0.8	0.215
Heart weight, mg	141 ± 4	167 ± 5‡	152 ± 4	151 ± 3§	<0.001
Heart weight/TL, mg/mm	8.18 ± 0.78	9.44 ± 0.03†	8.58 ± 0.83	8.63 ± 0.83	<0.01
LV weight, mg	100 ± 4	120 ± 4†	105 ± 4	107 ± 3	<0.01
LV weight/TL, mg/mm	5.83 ± 0.79	6.76 ± 0.88†	5.89 ± 0.83§	6.12 ± 0.72§	<0.01
Lung weight, wet/dry	1.20 ± 0.15	1.21 ± 0.19	1.22 ± 0.18	1.21 ± 0.17	0.649
Liver weight, wet/dry	1.75 ± 0.34	1.87 ± 0.33∗	1.78 ± 0.30	1.78 ± 0.25	<0.05

Values are mean ± SEM. n = 12. Mice were sacrificed after 16 weeks on treatment, and organs were weighed and LV was prepared for microscopy.

CD = control diet; HFHS = high-fat, high-sucrose diet; LV = left ventricle; SAC/VAL = sacubitril/valsartan; TL = tibia length; VAL = valsartan.

^∗p < 0.05 vs. CD;

^†p < 0.01 vs. CD;

^‡p < 0.001 vs. CD;

^§p < 0.05 vs. HFHS.