Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 29;10:332. doi: 10.1038/s41398-020-01018-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Locus: chromosome and position of the AD-associated genetic variants (coordinates are with respect to GRCh37). N. genes: total number of genes associated with each variant according to variant-gene mapping. Variant-gene mapping: Genes: all genes with at least one annotation to the five selected molecular pathways associated with AD. Weight: the weight of the variant-gene mapping. Gene-pathway mapping: immune response, beta-amyloid, endocytosis, cholesterol/lipid, angiogenesis: the weight of each molecular pathway at the gene level. Variant-pathway mapping: summarization of each variant’s effect after combining variant-gene and gene-pathway mappings. Red crosses indicate unmapped genes.