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. 2020 Sep 29;10:332. doi: 10.1038/s41398-020-01018-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a shows the effect-sizes (log of odds ratio) and the relative 95% confidence intervals of the association of the (p)PRS with both AD-risk and resilience against AD, grouped by pathway. In b, each bar represents the ratio between the effect-size of the association with escaping AD (Resilience effect in a) and with causing AD (Risk effect in a), respectively, with and without APOE variants. Ratios larger than 1 are then indicative of larger effect-size on resilience against AD compared to AD-risk. We then compared the change in effect-size for each pathway when including and excluding APOE variants using t-tests. Annotation: ***p-value of association < 5 × 10⁻⁶; **p-value of association < 5 × 10⁻⁴; *p-value of association < 5 × 10⁻².