Table 2.
Metabolic measures
| Variable | Men without OSA (n = 15) | Men with OSA (n = 15) | p value |
|---|---|---|---|
| Fasting plasma glucose (mmol/l) | 5.8 (0.3) | 6.3 (0.4) | p < 0.001 |
| Fasting serum insulin (mU/l) | 8.0 (4.9) | 8.6 (3.8) | 0.548 |
| Glucose, OGTT AUC120 min (min × mmol/l) | 938 (114) | 1128 (119) | p < 0.001 |
| Insulin, OGTT AUC120 min (min × mU/l) | 5241 (3340) | 5404 (1893) | 0.865 |
| 2-h plasma glucose (mmol/l) | 7.0 (1.3) | 8.8 (1.5) | 0.001 |
| Serum C-peptide (nmol/l) | 0.7 (0.2) | 0.9 (0.2) | 0.039 |
| HbA1c (mmol/mol, IFCC) | 36.4 (2.4) | 36.5 (2.7) | 0.880 |
| Fasting plasma triglycerides (mmol/l) | 1.0 (0.4) | 1.2 (0.4) | 0.189 |
| Fasting plasma HDL cholesterol (mmol/l) | 1.3 (0.1) | 1.3 (0.3) | 0.901 |
| Fasting plasma LDL cholesterol (mmol/l) | 3.4 (0.9) | 3.5 (0.7) | 0.708 |
| LDL/HDL | 2.7 (0.8) | 3.0 (1.0) | 0.442 |
| Fasting plasma NEFA (μM) | 214 (77) | 263 (87) | 0.097 |
| Fasting plasma glycerol (μM) | 77 (29) | 76 (23) | 0.686 |
| NEFA, OGTT AUC120 min (min × μmol/l) | 11,413 (3694) | 14,905 (4633) | 0.021 |
| Glycerol, OGTT AUC120 min (min × μmol/l) | 6840 (2173) | 7416 (2479) | 0.475 |
| Fasting plasma total GLP-1 (pmol/l) | 17 (8.0) | 18 (9.0) | 0.864 |
| GLP-1 total AUC120 min (min × pmol/l) | 2564 (1221) | 2935 (1318) | 0.413 |
Data are shown as mean (SD). Blood samples were obtained during fasting or OGTT as indicated. The p values are from crude linear regression analyses with bootstrapped standard errors
HbA1c glycated hemoglobin (HbA1c), measured in whole blood, HDL high-density lipoprotein, LDL Low-density lipoprotein, NEFA nonesterified fatty acids, OGTT oral glucose tolerance test