Table 3.
Association between receiving vaccinations at age two and five years and maternal mental illness
| Up to date vaccinations at | Number vaccinated (%) | Number not vaccinated (%) | Unadjusted model | Adjusted model-1a | Adjusted model-2b | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI)a | p value | OR (95% CI)b | p value | |||
| 2 Year | ||||||||
| Unexposed to maternal mental illness | 338,398 (88.0) | 46,116 (12.0) | REF | REF | REF | |||
| Exposed to any maternal mental illness | 82,361 (86.3) | 13,074 (13.7) | 0.86 (0.84–0.88) | < 0.001 | 0.86 (0.84–0.88) | < 0.001 | 0.86 (0.84–0.88) | < 0.001 |
| Psychotic disorder | 973 (86.9) | 147 (13.1) | 0.90 (0.75–1.08) | 0.267 | 0.86 (0.71–1.03) | 0.103 | 0.85 (0.70–1.02) | 0.088 |
| Depressive disorder | 67,241 (86.1) | 10,821 (13.9) | 0.85 (0.83–0.87) | < 0.001 | 0.86 (0.84–0.88) | < 0.001 | 0.86 (0.84–0.88) | < 0.001 |
| Anxiety disorder | 25,052 (86.6) | 3880 (13.4) | 0.88 (0.85–0.91) | < 0.001 | 0.86 (0.83–0.89) | < 0.001 | 0.86 (0.82–0.89) | < 0.001 |
| Eating disorder | 738 (86.4) | 116 (13.6) | 0.87 (0.71–1.06) | 0.174 | 0.94 (0.77–1.16) | 0.579 | 0.94 (0.76–1.15) | 0.533 |
| Personality disorder | 430 (86.0) | 70 (14.0) | 0.84 (0.65–1.09) | 0.181 | 0.75 (0.58–0.98) | 0.037 | 0.74 (0.57–0.97) | 0.029 |
| Substance and alcohol abuse | 1218 (78.6) | 331 (21.4) | 0.50 (0.44–0.57) | < 0.001 | 0.50 (0.44–0.58) | < 0.001 | 0.50 (0.44–0.57) | < 0.001 |
| 5 Year | ||||||||
| Unexposed to maternal mental illness | 188,399 (82.3) | 40,595 (17.7) | REF | REF | REF | |||
| Exposed to any maternal mental illness | 77,569 (79.9) | 19,519 (20.1) | 0.86 (0.84–0.87) | < 0.001 | 0.86 (0.84–0.88) | < 0.001 | 0.85 (0.84–0.87) | < 0.001 |
| Psychotic disorder | 1024 (77.6) | 295 (22.4) | 0.75 (0.65–0.86) | < 0.001 | 0.71 (0.62–0.82) | < 0.001 | 0.71 (0.61–0.81) | < 0.001 |
| Depressive disorder | 63,302 (79.8) | 16,053 (20.2) | 0.85 (0.83–0.87) | < 0.001 | 0.86 (0.84–0.88) | < 0.001 | 0.85 (0.83–0.87) | < 0.001 |
| Anxiety disorder | 29,291 (79.7) | 7453 (20.3) | 0.85 (0.82–0.87) | < 0.001 | 0.84 (0.82–0.87) | < 0.001 | 0.84 (0.81–0.86) | < 0.001 |
| Eating disorder | 884 (78.7) | 240 (21.4) | 0.79 (0.68–0.93) | 0.004 | 0.83 (0.71–0.98) | 0.024 | 0.83 (0.71–0.99) | 0.018 |
| Personality disorder | 454 (76.4) | 140 (23.6) | 0.70 (0.57–0.85) | < 0.001 | 0.64 (0.52–0.78) | < 0.001 | 0.63 (0.51–0.77) | < 0.001 |
| Substance and alcohol abuse | 1354 (70.0) | 580 (30.0) | 0.50 (0.45–0.56) | < 0.001 | 0.50 (0.45–0.56) | < 0.001 | 0.50 (0.45–0.55) | < 0.001 |
aAdjusted for sex of the child, child ethnicity delivery year, maternal age, practice level deprivation quintile and region
bAdjusted for all variables in model one, plus number of GP visits nine months prior to the birth
See supplementary Tables 4 and 5 for estimates relating to adjusted variables